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| Tuesday, October 25th , 2050 |
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| Amarillo Warheads: Signed Manager Alfred Roberts. |
| Friday, October 21st , 2050 |
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| 3B Mick Jermy retired from professional baseball. |
| Surprise Shockers: RP Andrew Charles retired from professional baseball. |
| RP Bob Howard retired from professional baseball. |
| LF Iván Álvarez retired from professional baseball. |
| Bethlehem Angel Kitties: RP Andrew Hooper retired from professional baseball. |
| RP Eric Sanford retired from professional baseball. |
| RP Ángel Contreras retired from professional baseball. |
| RP José Bustamante retired from professional baseball. |
| Surprise Shockers: C Ienobu Sato retired from professional baseball. |
| CL Edolf Olthuis retired from professional baseball. |
| RP Ryan Cooper retired from professional baseball. |
| RP Li Yong retired from professional baseball. |
| 3B Annaber Jepleting retired from professional baseball. |
| CF Ni Sun retired from professional baseball. |
| 1B Harold Pither retired from professional baseball. |
| RP Rafael Medina retired from professional baseball. |
| RP Javier Canseco retired from professional baseball. |
| RP Wilson García retired from professional baseball. |
| Shady Side Zoomies: 3B Terry White retired from professional baseball. |
| C Felipe Escoto retired from professional baseball. |
| Surprise Shockers: RP Raúl Nieves retired from professional baseball. |
| RP Víctor Valdés retired from professional baseball. |
| 2B Jelmar Loeve retired from professional baseball. |
| RP Sergio Pérez retired from professional baseball. |
| Surprise Shockers: RP Jaffar Khosa retired from professional baseball. |
| C José Contreras retired from professional baseball. |
| RP Yaichiro Ohayashi retired from professional baseball. |
| RP Javier González retired from professional baseball. |
| 1B Francisco Esparza retired from professional baseball. |
| 2B Balltesar Montezinho retired from professional baseball. |
| RP Tony Castro retired from professional baseball. |
| Surprise Shockers: RP Tomás Ivanic retired from professional baseball. |
| RP Luis Ríos retired from professional baseball. |
| SS Roberto Concepción retired from professional baseball. |
| RF Tim Wilson retired from professional baseball. |
| C Joe Schroeder retired from professional baseball. |
| 3B David Trujillo retired from professional baseball. |
| 1B Dan Murphy retired from professional baseball. |
| 2B Bruce Hill retired from professional baseball. |
| 3B Stephen Wilson retired from professional baseball. |
| 2B Harold Townsend retired from professional baseball. |
| C Miguel Escobar retired from professional baseball. |
| C Yoshiyuki Kimura retired from professional baseball. |
| C Saqr Siraj retired from professional baseball. |
| RP Jyri Vihko retired from professional baseball. |
| North Ft. Myers Gators: Pitching Coach José Silva retires. |
| Germantown Uruguayans: Manager Júlio Aguirre leaves the team, his contract was not renewed |
| North Ft. Myers Gators: Manager Gilberto Chávez leaves the team, his contract was not renewed |
| Amarillo Warheads: Manager Terry Johnson leaves the team, his contract was not renewed |
| Friday, September 23rd , 2050 |
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| Bompton Baby Lakers: Activated 3B Jesús Rosas from the injured list. |
| Bompton Baby Lakers: Activated SP Ed Taylor from the injured list. |
| Thursday, September 15th , 2050 |
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| Fort Knox Centennial: Signed -name %name to a %number-year contract extension. |
| Sunday, September 11th , 2050 |
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| North Ft. Myers Gators: Activated SP Chaim van den Akker from the injured list. |
| Surprise Shockers: Hitting Coach Rick Pierce retires. |
