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| Monday, December 5th , 2050 |
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| Plattsburgh Puffer Fish: RP Tony Ayala becomes a free-agent. |
| Saturday, November 5th , 2050 |
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| Hicksville Hounds: Signed Manager Phil Carroll. |
| Monday, October 24th , 2050 |
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| Tulsa Otters: Signed Manager Ben Cooper. |
| Friday, October 21st , 2050 |
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| SP Michael Daniels retired from professional baseball. |
| RP Anthony Lewis retired from professional baseball. |
| RP Manny Juárez retired from professional baseball. |
| 2B Alfredo Ramos retired from professional baseball. |
| RP Juan Bonilla retired from professional baseball. |
| Hudsonville Flanderses: RP Xiao-yong Fen retired from professional baseball. |
| RP Norinaga Ishii retired from professional baseball. |
| RP Takuma Ozawa retired from professional baseball. |
| CF Ming-feng Won retired from professional baseball. |
| C Sergio Rodríguez retired from professional baseball. |
| RP Jin-u Ch'oe retired from professional baseball. |
| RP Victor Emondt retired from professional baseball. |
| RP Tadakuni Ogawa retired from professional baseball. |
| RP Stan Bowden retired from professional baseball. |
| 2B Wesley Watkins retired from professional baseball. |
| 2B Dennie Adriani retired from professional baseball. |
| RP Derek Parry retired from professional baseball. |
| RP José Córdova retired from professional baseball. |
| RP Paco Ortíz retired from professional baseball. |
| SS Tomás Aguilar retired from professional baseball. |
| 1B Umarah Muneer retired from professional baseball. |
| Tulsa Otters: RP Daniel Rivera retired from professional baseball. |
| LF Roberto Campos retired from professional baseball. |
| Tulsa Otters: RP Cheng-en Wang retired from professional baseball. |
| 2B Kelsey Franken retired from professional baseball. |
| SP José Lucero retired from professional baseball. |
| 2B António Morales retired from professional baseball. |
| SP Jose Gonzales retired from professional baseball. |
| 2B Jean Grégoire retired from professional baseball. |
| Greenport Harbor Whales: RP Steven D'antonio retired from professional baseball. |
| RP Gary Britton retired from professional baseball. |
| 2B Allan Evans retired from professional baseball. |
| RP Kelsey Baker retired from professional baseball. |
| RP Rusty Pennington retired from professional baseball. |
| 1B Stefan Hill retired from professional baseball. |
| Hudsonville Flanderses: Pitching Coach John Erickson retires. |
| Redwood Rhinos: Hitting Coach Bob Sosa leaves the team, his contract was not renewed |
| Beaumont Crossbeaus: Manager Steve Ferguson leaves the team, his contract was not renewed |
| Beaumont Crossbeaus: Hitting Coach Javier Zumaya leaves the team, his contract was not renewed |
| Beaumont Crossbeaus: Pitching Coach Michel Neveu leaves the team, his contract was not renewed |
| Hicksville Hounds: Manager Oliver Burrell leaves the team, his contract was not renewed |
| Hicksville Hounds: Pitching Coach Brian King leaves the team, his contract was not renewed |
| Plattsburgh Puffer Fish: Pitching Coach Hao Wei leaves the team, his contract was not renewed |
| Tuesday, September 13th , 2050 |
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| Quebec City Baby Blues: Activated SP Sherman Travis from the injured list. |
| Quebec City Baby Blues: Activated SS John Robinson from the injured list. |
| Redwood Rhinos: Activated RP Juan Romero from the injured list. |
| Redwood Rhinos: Activated SS Gerardo Sotelo from the injured list. |
| Redwood Rhinos: Activated SP Jorge López from the injured list. |
| Tulsa Otters: Manager Ken Beach retires. |
| Quebec City Baby Blues: Activated C Ron Sullivan from the injured list. |
