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| Saturday, November 3rd , 2046 |
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| Barton Springs Blues: Signed Manager Joe Kehoe. |
| Thursday, November 1st , 2046 |
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| Crescent City Krewe: Fired Pitching Coach Denver Johnston. |
| Crescent City Krewe: Fired Hitting Coach Tracy Williams. |
| Crescent City Krewe: Signed Manager David Martínez. |
| Wednesday, October 24th , 2046 |
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| LF Luis Pérez retired from professional baseball. |
| Lake Minnetonka Love Boats: RP Jonathan Cooper retired from professional baseball. |
| SP Wilson Tamayo retired from professional baseball. |
| RP Hyeon-uk Sa retired from professional baseball. |
| Ithaca Fighting Imps: CF Daryl Pethick retired from professional baseball. |
| RP Kuniyuki Sugimoto retired from professional baseball. |
| SP Lang Lian retired from professional baseball. |
| 1B Lucas Palgani retired from professional baseball. |
| SP Ronald Reddaway retired from professional baseball. |
| C Ace Felder retired from professional baseball. |
| Ithaca Fighting Imps: 1B Bob Sims retired from professional baseball. |
| 3B John Jackson retired from professional baseball. |
| SP Jorge Bigro retired from professional baseball. |
| SP Arturo Pérez retired from professional baseball. |
| SP Chun-mei Bao retired from professional baseball. |
| RP Aleksandr Lovenetsky retired from professional baseball. |
| Ithaca Fighting Imps: C Claude Long retired from professional baseball. |
| Yakima Hops: CF Jaime Juárez retired from professional baseball. |
| SS Oliver Buss retired from professional baseball. |
| C Kung Wan retired from professional baseball. |
| SS Ken Gil retired from professional baseball. |
| Asheville Highlanders: RP Tobin Basch retired from professional baseball. |
| RP Carlos Coronado retired from professional baseball. |
| RP Curt Ladner retired from professional baseball. |
| Ithaca Fighting Imps: RP Reid Ross retired from professional baseball. |
| 3B Zak Arrington retired from professional baseball. |
| SP Bryan Workman retired from professional baseball. |
| RP Tim Little retired from professional baseball. |
| SP Devin Alvarado retired from professional baseball. |
| RP Robert Young retired from professional baseball. |
| Yakima Hops: RP David López retired from professional baseball. |
| RP Theo Von Heezik retired from professional baseball. |
| Ottawa Nationals: RP Anthony Dixon retired from professional baseball. |
| SP Bill Salas retired from professional baseball. |
| SP Arlen Jones retired from professional baseball. |
| RP Jessie Huber retired from professional baseball. |
| Manager Felipe Jiméniz retires. |
| Billings Polar Bears: Pitching Coach Clinton Anderson leaves the team, his contract was not renewed |
| Barton Springs Blues: Signed Hitting Coach Ed Patterson to a 2-year contract extension. |
| Yakima Hops: Pitching Coach Charlie Hall leaves the team, his contract was not renewed |
| Irving Blue Sox: Hitting Coach Andy Harris leaves the team, his contract was not renewed |
| Casper Ghosts: Hitting Coach Noel Livingston leaves the team, his contract was not renewed |
| Crescent City Krewe: Manager Tim Norris leaves the team, his contract was not renewed |
| Sunday, October 7th , 2046 |
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| Yakima Hops: Placed SP Darryl Bailey on the active roster. |
| Yakima Hops: Placed SP Yoshifumi Oshima on the active roster. |
| Irving Blue Sox: Placed SP Jeffrey Eckert on the active roster. |
| Irving Blue Sox: Placed RP Jian-ying Yep on the active roster. |
| Irving Blue Sox: Placed CF Kenny Jones on the active roster. |
| Thursday, September 27th , 2046 |
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| Lancaster Farmers: Pitching Coach Luis Díaz retires. |
