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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Francisco Burgos | 0.853 | 2028 | |
| 2 | Marlon Harris# | 1.072 | 2044 | |
| 3 | Armando Ortíz | 1.177 | 2025 | |
| 4 | Paul Addison | 1.186 | 2026 | |
| 5 | Tomás Vargas | 1.280 | 2026 | |
| 6 | Benjamin Busto | 1.319 | 2027 | |
| 7 | Sylvain Richard# | 1.350 | 2040 | |
| 8 | William Averett# | 1.354 | 2043 | |
| 9 | Ismael Soto | 1.355 | 2021 | |
| 10 | Tony Solíz | 1.376 | 2024 | |
| 11 | Edison Carter | 1.435 | 2037 | |
| 12 | Bob Browning | 1.450 | 2025 | |
| 13 | Edward Martin# | 1.563 | 2042 | |
| 14 | José Cotilla | 1.577 | 2029 | |
| 15 | Baruc Garibay | 1.627 | 2027 | |
| 16 | Loren Berdine | 1.641 | 2029 | |
| 17 | Iván Vázquez# | 1.662 | 2027 | |
| 18 | Ronald Love# | 1.712 | 2045 | |
| 19 | Felipe Lozano | 1.748 | 2028 | |
| 20 | Min-chin Kim | 1.779 | 2029 | |
| 21 | Greg Hoover# | 1.824 | 2038 | |
| 22 | Don Bender | 1.831 | 2020 | |
| 23 | Jorge Travieso | 1.832 | 2028 | |
| 24 | Ángel Franco# | 1.874 | 2043 | |
| 25 | Alberto Solís | 1.885 | 2027 | |
| 26 | Júlio Vázquez | 1.912 | 2026 | |
| 27 | Steve Young# | 1.924 | 2040 | |
| 28 | Kenzaburo Hakui# | 1.929 | 2037 | |
| 29 | Enrique Castro | 1.933 | 2027 | |
| 30 | Kong Li | 1.948 | 2035 | |
| 31 | Santiago Alonza | 1.958 | 2023 | |
| 32 | Will Hoffman | 1.964 | 2029 | |
| 33 | Bhagavan Antle# | 1.972 | 2041 | |
| 34 | Jordon Glen Anderson# | 1.973 | 2040 | |
| 35 | Hsin-ta Lian# | 1.978 | 2041 | |
| 35 | Tony Moreno | 1.978 | 2028 | |
| 37 | Bobby Roode | 1.987 | 2030 | |
| 38 | Luis Hernández | 2.017 | 2025 | |
| 39 | Maru Pao Pao | 2.030 | 2027 | |
| 39 | Juan López | 2.030 | 2021 | |
| 39 | Francisco Burgos | 2.030 | 2027 | |
| 42 | Tyler Lund | 2.048 | 2026 | |
| 43 | Ron Madison | 2.053 | 2020 | |
| 44 | Javier Ariza# | 2.055 | 2036 | |
| 44 | Ernesto Méndez | 2.055 | 2034 | |
| 44 | Sam Martínez# | 2.055 | 2042 | |
| 47 | Rusty Swanson | 2.056 | 2025 | |
| 48 | Ramón Castaneda | 2.057 | 2025 | |
| 49 | Claudio Mateo | 2.064 | 2029 | |
| 50 | Darius Baxa | 2.098 | 2026 | |
| 51 | Gabriel Escobar | 2.101 | 2025 | |
| 52 | Osiris St. Brown | 2.103 | 2028 | |
| 53 | Sean Halls | 2.111 | 2036 | |
| 54 | Steve Baker# | 2.112 | 2042 | |
| 54 | Mark Parker | 2.112 | 2033 | |
| 56 | Brad Cunnick | 2.114 | 2020 | |
| 57 | Jeff Lee | 2.122 | 2020 | |
| 57 | Rust Cohle | 2.122 | 2025 | |
| 59 | Alberto Mendoza | 2.127 | 2025 | |
| 60 | Valentin Calhamar# | 2.134 | 2034 | |
| 60 | Madanraj Velusamy | 2.134 | 2030 | |
| 62 | Marco Sledge | 2.139 | 2028 | |
| 63 | Elliot Reid# | 2.144 | 2043 | |
| 64 | Edward Scarborough | 2.150 | 2027 | |
| 65 | Nicholas Beyer | 2.167 | 2022 | |
| 66 | Pedro Álvarez | 2.176 | 2020 | |
| 67 | Javier Vallejo | 2.184 | 2036 | |
| 68 | Rich Roberts# | 2.185 | 2043 | |
| 69 | Song-saeng Kim | 2.195 | 2022 | |
| 70 | Alejandro Ramos | 2.201 | 2023 | |
| 71 | Volmer Aalbers# | 2.217 | 2044 | |
| 72 | Santos Guzowski | 2.227 | 2025 | |
| 73 | Rick Hubbard | 2.233 | 2039 | |
| 74 | Manuel Ceja | 2.245 | 2027 | |
| 75 | Harry Stuterberg# | 2.250 | 2033 | |
| 75 | Quinton Richards | 2.250 | 2027 | |
| 77 | António Muñóz | 2.254 | 2027 | |
| 78 | Ernest Torres | 2.256 | 2020 | |
| 79 | Abdel Alamini | 2.263 | 2026 | |
| 80 | Nick Richie | 2.268 | 2023 | |
| 81 | Prince Nakamura | 2.271 | 2023 | |
| 82 | Raymond Beauregard | 2.285 | 2028 | |
| 83 | Won-min Yi | 2.288 | 2027 | |
| 84 | Pedro Ramírez | 2.292 | 2021 | |
| 85 | Victor de Meij | 2.294 | 2024 | |
| 85 | António Martínez | 2.294 | 2032 | |
| 87 | Balltesar Patalim# | 2.304 | 2045 | |
| 88 | Mark Bell | 2.305 | 2021 | |
| 89 | Roger Murdock | 2.308 | 2027 | |
| 90 | Kewiki Pua | 2.319 | 2030 | |
| 91 | Donnie Rawling | 2.332 | 2036 | |
| 92 | Vicente Romero | 2.344 | 2028 | |
| 93 | Adrian Neumann | 2.345 | 2021 | |
| 94 | Júlio del Bosque# | 2.348 | 2037 | |
| 95 | Ángel Gardener | 2.353 | 2031 | |
| 96 | Dennis Blanchard | 2.359 | 2031 | |
| 97 | Walt Cooley | 2.363 | 2024 | |
| 98 | Ramiro García | 2.367 | 2022 | |
| 99 | Dario Zorander# | 2.378 | 2040 | |
| 100 | Alejandro Ramos | 2.385 | 2024 |
