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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Raúl Romero# | 2.36 | 2035-2042 | |
| 2 | Todd Hines* | 2.52 | 2018-2032 | |
| 3 | Sozen Raikatuji* | 2.59 | 2016-2023 | |
| 4 | Ryan Davis* | 2.62 | 2015-2026 | |
| 5 | Devin Hinton | 2.66 | 2013-2023 | |
| 6 | Ryan Ray | 2.79 | 2013-2021 | |
| 6 | Jesús Franco | 2.79 | 2026-2033 | |
| 8 | Iván García | 2.82 | 2021-2035 | |
| 9 | Jim Eliott* | 2.83 | 2014-2025 | |
| 10 | Guillermo García | 2.85 | 2013-2021 | |
| 11 | Ralph McKinney* | 2.88 | 2019-2034 | |
| 12 | Lúcio Sánchez* | 2.90 | 2017-2031 | |
| 13 | Yuri Volkers | 2.92 | 2013-2021 | |
| 14 | Jesús Caldero | 2.93 | 2018-2027 | |
| 15 | Bruce Wright | 2.95 | 2020-2030 | |
| 16 | Sjaak Bonne | 2.98 | 2025-2041 | |
| 17 | Jorge Aguirre* | 3.00 | 2015-2032 | |
| 18 | Eric Matson | 3.01 | 2028-2042 | |
| 19 | Jesús Gonzáles | 3.02 | 2019-2030 | |
| 19 | José Hernández | 3.02 | 2013-2023 | |
| 21 | Pedro Alejándrez* | 3.04 | 2021-2034 | |
| 21 | Edwin Ellis | 3.04 | 2013-2019 | |
| 23 | Bill Oulton | 3.13 | 2021-2034 | |
| 23 | John Wilkins* | 3.13 | 2013-2028 | |
| 25 | Cris Mendoza | 3.15 | 2013-2029 | |
| 25 | John Kaufman* | 3.15 | 2017-2032 | |
| 27 | Chester Henry | 3.16 | 2016-2023 | |
| 28 | Manuel Rojas | 3.17 | 2018-2028 | |
| 28 | Cordell Wilson | 3.17 | 2019-2030 | |
| 30 | Jorge Otero | 3.18 | 2031-2041 | |
| 31 | Vincent Hall | 3.21 | 2020-2032 | |
| 31 | Ramón Ortega* | 3.21 | 2013-2028 | |
| 33 | Tom Reynolds* | 3.22 | 2015-2028 | |
| 34 | Yoriyoshi Yamamoto | 3.25 | 2016-2026 | |
| 35 | Edgardo Marín | 3.29 | 2013-2032 | |
| 36 | Alec Pittman | 3.31 | 2016-2030 | |
| 37 | Pedro Ortíz | 3.32 | 2020-2038 | |
| 38 | Tony Alfonso# | 3.41 | 2033-2042 | |
| 39 | Aurelio López | 3.42 | 2022-2036 | |
| 40 | Juan Júlio | 3.45 | 2013-2026 | |
| 41 | Raúl Gómez | 3.48 | 2027-2033 | |
| 41 | Wayne Craig | 3.48 | 2018-2030 | |
| 41 | Ilie Paunescu | 3.48 | 2016-2035 | |
| 44 | Curtis Fields | 3.49 | 2016-2024 | |
| 44 | George Frazier | 3.49 | 2019-2037 | |
| 44 | John Dempsey | 3.49 | 2022-2037 | |
| 47 | Pat Farrell | 3.53 | 2013-2022 | |
| 48 | Wes Hamm* | 3.55 | 2021-2037 | |
| 48 | Alejandro Guerra | 3.55 | 2027-2037 | |
| 48 | Billy Crawford | 3.55 | 2014-2025 | |
| 51 | Eddie Kop | 3.56 | 2025-2042 | |
| 52 | Miguel Rubia | 3.57 | 2029-2040 | |
| 53 | Germán Rodríguez | 3.58 | 2024-2039 | |
| 54 | Gerardo Pagán# | 3.60 | 2027-2042 | |
| 55 | Wayne Hurst | 3.63 | 2015-2024 | |
| 56 | Fraser Cuevas | 3.64 | 2020-2032 | |
| 57 | Gary Ashley# | 3.65 | 2035-2042 | |
| 57 | Raúl Areola | 3.65 | 2020-2033 | |
| 59 | Keisuke Nishida | 3.66 | 2029-2036 | |
| 60 | Burt Booth | 3.67 | 2013-2026 | |
| 61 | Andrew Moody# | 3.68 | 2032-2042 | |
| 62 | José García | 3.69 | 2022-2035 | |
| 63 | Enrique Cortéz | 3.70 | 2022-2032 | |
| 64 | Juan Torres | 3.71 | 2023-2029 | |
| 65 | Kenny Aarnoutse# | 3.75 | 2032-2042 | |
| 66 | Kirby Brown | 3.76 | 2017-2029 | |
| 67 | José Flores | 3.80 | 2019-2029 | |
| 68 | Bill Fletcher | 3.81 | 2018-2025 | |
| 68 | Mimosa Joseph | 3.81 | 2023-2035 | |
| 70 | Miguel Castillo | 3.82 | 2013-2020 | |
| 71 | Luis Flores | 3.83 | 2024-2033 | |
| 72 | Ramón Molina | 3.89 | 2026-2034 | |
| 73 | Jaime van de Weideven | 3.91 | 2022-2038 | |
| 74 | Rhys Maskell# | 3.93 | 2035-2042 | |
| 75 | Ricardo García# | 3.98 | 2031-2042 | |
| 75 | Mario Peña | 3.98 | 2013-2023 | |
| 77 | Yoo-chul Mun | 4.01 | 2031-2039 | |
| 78 | Enrique Magana | 4.04 | 2013-2019 | |
| 79 | Josef van der Poel | 4.05 | 2019-2035 | |
| 80 | Vern Camp | 4.08 | 2013-2022 | |
| 81 | Addie Samson | 4.11 | 2021-2035 | |
| 82 | Cristián Moreno# | 4.14 | 2034-2042 | |
| 83 | Firpo Marberry# | 4.19 | 2036-2042 | |
| 84 | Giovanni Mireles# | 4.21 | 2029-2041 | |
| 84 | Sjoerd Reynoud# | 4.21 | 2034-2042 | |
| 86 | Tobías Pérez | 4.27 | 2024-2037 | |
| 87 | Natalino Golaio | 4.28 | 2023-2040 | |
| 88 | Sam Mooney | 4.30 | 2028-2040 | |
| 89 | Sy-ing Tah | 4.31 | 2030-2039 | |
| 89 | Pablo De La Torre | 4.31 | 2021-2038 | |
| 91 | Elroy Thompkins# | 4.32 | 2029-2041 | |
| 92 | Yin-fat Foong | 4.36 | 2017-2029 | |
| 92 | Cole Hall | 4.36 | 2013-2027 | |
| 94 | Robert Smalls# | 4.43 | 2036-2042 | |
| 95 | Miguel Angel Martínez# | 4.44 | 2034-2042 | |
| 96 | Calvin Beck | 4.45 | 2026-2033 | |
| 97 | José Cotilla# | 4.53 | 2032-2042 | |
| 98 | Luis Peña | 4.54 | 2025-2037 | |
| 98 | Gerald Keller | 4.54 | 2030-2036 | |
| 100 | Ambrose Randall# | 4.59 | 2027-2039 |
