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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | José Lucero# | 0.82 | 2030-2036 | |
| 2 | Yuri Volkers | 1.09 | 2013-2021 | |
| 3 | Mitchell Atwell# | 1.17 | 2027-2037 | |
| 3 | Gavin Blackburn | 1.17 | 2018-2031 | |
| 3 | José Sánchez# | 1.17 | 2027-2037 | |
| 6 | Manny Amici# | 1.38 | 2025-2037 | |
| 7 | Ted Locke | 1.42 | 2018-2026 | |
| 8 | Javier Dávila | 1.43 | 2024-2031 | |
| 9 | Nand Lal Chaudhary# | 1.63 | 2033-2036 | |
| 10 | Ismael Barrios | 1.64 | 2024-2026 | |
| 10 | Robinson Gonzáles | 1.64 | 2020-2031 | |
| 12 | Cristián Moreno# | 1.68 | 2034-2038 | |
| 13 | Brandon Bannatyne | 1.79 | 2017-2032 | |
| 14 | Christian Mustard# | 1.84 | 2028-2038 | |
| 15 | Roy Robinson | 1.87 | 2013-2023 | |
| 16 | Roberto Ortega | 1.93 | 2019-2020 | |
| 17 | Maxime Janssens# | 1.95 | 2030-2038 | |
| 18 | Todd Hines* | 2.03 | 2018-2032 | |
| 19 | José Ramos | 2.04 | 2014-2023 | |
| 20 | Bryan Houston | 2.06 | 2020-2024 | |
| 21 | Sjaak Bonne# | 2.08 | 2025-2038 | |
| 21 | António Vega | 2.08 | 2013-2023 | |
| 23 | Armando Hernández | 2.15 | 2013-2018 | |
| 24 | Pancho Padilla | 2.16 | 2024-2030 | |
| 25 | Torvald Geertsen | 2.17 | 2018-2024 | |
| 26 | Armando Garay# | 2.18 | 2031-2037 | |
| 27 | Francisco Valdés | 2.19 | 2023-2034 | |
| 28 | Dave Reed | 2.20 | 2019-2031 | |
| 29 | Miguel Rubia# | 2.21 | 2029-2038 | |
| 29 | Joe Kehoe | 2.21 | 2022-2028 | |
| 31 | Mauro Guerra | 2.25 | 2024-2029 | |
| 31 | Juan Sánchez | 2.25 | 2020-2026 | |
| 33 | William Johnson | 2.26 | 2013-2018 | |
| 34 | Jaime Carrión | 2.27 | 2026-2030 | |
| 35 | Alfonso Zapata | 2.29 | 2020-2034 | |
| 36 | Jason Hubbell | 2.31 | 2020-2029 | |
| 36 | Jesús Gonzáles | 2.31 | 2019-2030 | |
| 38 | Juan Guillén# | 2.34 | 2026-2038 | |
| 39 | Joy-shan Men# | 2.35 | 2036-2038 | |
| 39 | Kyung-un Yi | 2.35 | 2020-2030 | |
| 41 | John Wilkins* | 2.36 | 2013-2028 | |
| 42 | Jesús Caldero | 2.38 | 2018-2027 | |
| 43 | Cordell Wilson | 2.39 | 2019-2030 | |
| 44 | Iván García | 2.42 | 2021-2035 | |
| 45 | Sozen Raikatuji | 2.43 | 2016-2023 | |
| 46 | Javier Mora | 2.44 | 2022-2029 | |
| 46 | Santiago Alonza# | 2.44 | 2027-2038 | |
| 48 | Nebosja Draskovic# | 2.45 | 2034-2037 | |
| 49 | Myles Wilkerson | 2.47 | 2026-2035 | |
| 50 | Aki Tanaka | 2.48 | 2018-2022 | |
| 50 | Enrico Reséndez | 2.48 | 2021-2033 | |
| 52 | Chester Henry | 2.50 | 2016-2023 | |
| 52 | Júlio Rodríguez# | 2.50 | 2023-2038 | |
| 54 | Earnest Casey | 2.51 | 2018-2025 | |
| 54 | Piotr Oja | 2.51 | 2030-2034 | |
| 56 | Firpo Marberry# | 2.53 | 2036-2038 | |
| 57 | Brian Fixel# | 2.54 | 2028-2038 | |
| 58 | Anderson O'Mara# | 2.55 | 2026-2036 | |
| 59 | Mark Valle# | 2.58 | 2028-2038 | |
| 60 | Asher Spivey | 2.60 | 2027-2035 | |
| 61 | Addie Samson | 2.61 | 2021-2035 | |
| 61 | Juan Chávez | 2.61 | 2018-2020 | |
| 61 | Craig Gasnier | 2.61 | 2021-2023 | |
| 61 | Tony Hernández | 2.61 | 2013-2025 | |
| 65 | José García | 2.63 | 2022-2035 | |
| 66 | Alejandro Guerra# | 2.64 | 2027-2037 | |
| 67 | Jesús Franco | 2.65 | 2026-2033 | |
| 68 | Melvin Tiburcio# | 2.66 | 2033-2038 | |
| 69 | Yajirobei Otomo# | 2.68 | 2028-2038 | |
| 70 | Edwin Ellis | 2.73 | 2013-2019 | |
| 71 | Tom Reynolds* | 2.74 | 2015-2028 | |
| 71 | Javier Ramírez | 2.74 | 2018-2027 | |
| 73 | Ryan Davis* | 2.75 | 2015-2026 | |
| 74 | Lúcio Sánchez* | 2.76 | 2017-2031 | |
| 74 | Dan Crowder | 2.76 | 2028-2037 | |
| 76 | Charles Dobson | 2.79 | 2024-2032 | |
| 76 | Christian Bates | 2.79 | 2019-2022 | |
| 78 | Jeff Territt | 2.83 | 2022-2033 | |
| 79 | Dale Hamilton# | 2.84 | 2030-2038 | |
| 79 | Michael Fletcher | 2.84 | 2020-2024 | |
| 81 | Wayne Hurst | 2.86 | 2015-2024 | |
| 81 | John Kaufman | 2.86 | 2017-2032 | |
| 83 | Kevin Nogilny# | 2.88 | 2032-2038 | |
| 84 | José Flores | 2.90 | 2019-2029 | |
| 84 | Jim Eliott* | 2.90 | 2014-2025 | |
| 84 | Felipe Machado | 2.90 | 2026-2035 | |
| 87 | Eddie Kop# | 2.91 | 2025-2038 | |
| 88 | Mario Peńa | 2.92 | 2013-2023 | |
| 89 | Glenn Butler# | 2.93 | 2028-2038 | |
| 90 | Kyle Lewis | 2.94 | 2016-2026 | |
| 90 | Juan Torres | 2.94 | 2023-2029 | |
| 90 | Juan Júlio | 2.94 | 2013-2026 | |
| 93 | John Coleman | 2.95 | 2013-2025 | |
| 94 | Gerald Keller# | 2.96 | 2030-2036 | |
| 94 | Tony Solíz# | 2.96 | 2026-2035 | |
| 94 | Vincent Hall | 2.96 | 2020-2032 | |
| 94 | Roy Shively | 2.96 | 2030-2036 | |
| 98 | Ilie Paunescu | 2.97 | 2016-2035 | |
| 98 | Pedro Ritodíaz | 2.97 | 2013-2024 | |
| 100 | Yoriyoshi Yamamoto | 3.00 | 2016-2026 |
