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| Monday, November 22nd, 2021 |
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| Jasper Cougars: Signed Manager Màximo Aniceto to a 4-year contract extension. |
| Friday, November 5th, 2021 |
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| Saskatoon Smokin' Guns: Signed manager Larry Davenport. |
| Tuesday, October 26th, 2021 |
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| Lloydminster Lynx: Signed manager Pete Dale. |
| Sunday, October 24th, 2021 |
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| Chula Vista Tacos: Signed hitting coach Matt Sutton. |
| Saturday, October 23rd, 2021 |
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| Chula Vista Tacos: Signed pitching coach Conner Ruggles. |
| Monday, October 18th, 2021 |
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| Jasper Cougars: Released 1B Billy Campbell. |
| Lloydminster Lynx: Released MR Glen Brewer. |
| Lloydminster Lynx: Released CF Ánibal Moreno. |
| Saskatoon Smokin' Guns: Released SS Benny Gilbert. |
| Saskatoon Smokin' Guns: Released SP Jorge Gonzáles. |
| Saskatoon Smokin' Guns: Released SS Ramiro Gonzáles. |
| Chula Vista Tacos: Released SP Dan Fulk. |
| Chula Vista Tacos: Released CL Mark Stewart. |
| Chula Vista Tacos: Released MR Jaime Moreno. |
| Chula Vista Tacos: Released MR Mark Ross. |
| Colorado Commanders: Released 2B Pedro Delgado. |
| Salem Sledgehammers: Released SP Ed Cunningham. |
| Seattle Rainiers: Released CL Miguel Guerrero. |
| Seattle Rainiers: Released MR Paco Vega. |
| Lloydminster Lynx: Manager Allen Crawford leaves the team, his contract was not renewed. |
| Saskatoon Smokin' Guns: Manager Dave Leach leaves the team, his contract was not renewed. |
| Saskatoon Smokin' Guns: Pitching Coach Carlos Amador leaves the team, his contract was not renewed. |
| Saskatoon Smokin' Guns: Hitting Coach Alex Hanna leaves the team, his contract was not renewed. |
| Chula Vista Tacos: Pitching Coach Ramiro Villegas leaves the team, his contract was not renewed. |
| Chula Vista Tacos: Hitting Coach Raúl Martínez leaves the team, his contract was not renewed. |
| Colorado Commanders: Pitching Coach Norris Reid leaves the team, his contract was not renewed. |
