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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | José Fuentes# | 2.09 | 2025-2028 | |
| 2 | Gabriel Reyes# | 2.12 | 2026-2027 | |
| 3 | Malulani Anakone# | 2.14 | 2025-2028 | |
| 4 | Toshiharu Kuhabara# | 2.29 | 2025-2028 | |
| 4 | Manuel Sánchez# | 2.29 | 2026-2028 | |
| 6 | Kas Groen# | 2.43 | 2023-2026 | |
| 7 | Pedro Núñez# | 2.49 | 2021-2023 | |
| 8 | Fernando Elías# | 2.50 | 2024-2028 | |
| 9 | Baruc Garibay# | 2.51 | 2025-2026 | |
| 10 | Bartolo Ruíz# | 2.56 | 2024-2026 | |
| 11 | Carlos Ortega# | 2.69 | 2022-2026 | |
| 12 | Edgar Lankford# | 2.73 | 2023-2024 | |
| 13 | Carlos Díaz# | 2.74 | 2021-2022 | |
| 14 | Rob Ford# | 2.77 | 2026-2028 | |
| 15 | Vitorio Méndez | 2.79 | 2020-2025 | |
| 16 | Luis Arreola# | 2.82 | 2024-2027 | |
| 17 | Francisco Gonsáles# | 2.83 | 2022-2024 | |
| 17 | Felipe Becerra# | 2.83 | 2021-2025 | |
| 19 | Alberto Reyes# | 2.85 | 2020-2024 | |
| 20 | Sacco Brouwers# | 2.86 | 2022-2024 | |
| 21 | Ash Ibarra# | 2.88 | 2022-2024 | |
| 22 | Xavier Padilla# | 3.06 | 2021-2024 | |
| 23 | Luis Vega# | 3.08 | 2020-2023 | |
| 23 | José Pueblo# | 3.08 | 2026-2028 | |
| 25 | Gustavo Tobías# | 3.10 | 2026-2027 | |
| 26 | Esteban Ruíz# | 3.13 | 2021-2022 | |
| 26 | Leoncio Ulibarri# | 3.13 | 2023-2028 | |
| 28 | Ramón Luér# | 3.27 | 2026-2028 | |
| 29 | Gob Bluth# | 3.30 | 2024-2028 | |
| 30 | Will Hunting# | 3.37 | 2027-2028 | |
| 30 | Sook Sung-Man# | 3.37 | 2024-2026 | |
| 32 | John Orton# | 3.38 | 2022-2025 | |
| 33 | Burm Snart# | 3.50 | 2025-2027 | |
| 34 | Mike Harris# | 3.55 | 2022-2023 | |
| 34 | David Gómez# | 3.55 | 2021-2023 | |
| 36 | Reid Garrett# | 3.57 | 2023-2026 | |
| 37 | Rubén Rodríguez# | 3.59 | 2021-2022 | |
| 37 | Tomás Vargas# | 3.59 | 2023-2025 | |
| 39 | Pompeyo Davalillo# | 3.61 | 2024-2025 | |
| 40 | Yura Edel | 3.63 | 2021-2025 | |
| 41 | Jeff Greer# | 3.77 | 2026-2028 | |
| 42 | Horacio Pérez | 3.84 | 2020-2023 | |
| 42 | Ricardo Ramírez# | 3.84 | 2021-2025 | |
| 44 | Dave Seals# | 3.90 | 2023-2024 | |
| 45 | Eduardo Villa | 3.94 | 2021-2025 | |
| 46 | Baker Mayfield# | 4.03 | 2025-2026 | |
| 47 | Cheh Hao | 4.26 | 2024-2025 | |
| 48 | Jesús Otero# | 4.28 | 2023-2026 | |
| 49 | Mario Gonzáles# | 4.39 | 2022-2024 | |
| 50 | Bill Beauregard | 4.64 | 2020-2023 | |
| 51 | Alfredo Sánchez | 6.03 | 2020-2022 |
